| Pair Name | Tanshinone IIA, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | Tanshinone IIA (PubChem CID: 164676 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Tanshinone IIA, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| Up-regulation | Expression | TNFRSF10A | hsa8797 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| In Vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 |
| U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 | |
| In Vivo Model | Each mouse was injected subcutaneously with 0.2 mL of U87 cells (1×10⁵ cells/ml) at the hind limb. | |||
| Result | T-IIA increases TRAIL-induced apoptosis by downregulating STAT3 and upregulating DR4 and DR5, indicating T-IIA therapy as a novel treatment strategy for TRAIL-resistant GBM. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Tanshinone IIA sensitizes TRAIL-induced apoptosis in glioblastoma through inducing the expression of death receptors (and suppressing STAT3 activation). Brain Res. 2021 Sep 1;1766:147515. doi: 10.1016/j.brainres.2021.147515. | Click |
